Ultrasound BI-RADS and radiomics differ between HER2-low and HER2-0 triple-negative breast cancers

In 539 triple-negative breast cancers, HER2-low vs HER2-0 tumors showed different ultrasound vascularity (avascular: 6.3% vs 12.0%) and radiomics features; overall survival was similar, but HER2-low was associated with improved event-free survival in non-pCR patients.

• Among ultrasound BI-RADS characteristics, avascularity was less frequent in HER2-low tumors (6.3%) than HER2-0 (12.0%).
• No significant difference in pathologic complete response, event-free survival, or overall survival overall, but HER2-low status was associated with improved event-free survival in patients who did not achieve pCR.
• Radiomics revealed differences in shape, minimum voxel intensity, and texture.

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