Automated MRI Muscle Fat Fraction Correlates with Disease Severity and Functional Decline in CMT1A

Automated MRI muscle fat fraction quantification in CMT1A correlates with disease severity and functional impairment, with anterior compartment FF showing moderate correlations with stair climb time (r=0.68) and 6-min walk distance (r=-0.66).

• All compartmental and total FFs correlated positively with CMTNSv2 and FDS (r = 0.39–0.49, p < 0.05).
• Anterior compartment FF demonstrated the strongest functional correlations: stair climb time (r = 0.68) and 6-min walk distance (r = –0.66), both p < 0.001.
• The lateral compartment showed the highest FF (median 33.2%), consistent with the peroneal pattern of CMT1A.

Automated summary

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