AI-Guided Design Yields TROP-2-Targeting Peptide PET Tracer With Nanomolar Affinity

AI-designed peptide PET tracer [68Ga]Ga-DOTA-TR23 shows nanomolar affinity (KD=26.8 nM) for TROP-2, with rapid, specific tumor uptake and high contrast in pancreatic, prostate, and thyroid cancer mouse models.

• The tracer demonstrated high radiochemical purity (>95%) and stability in saline and serum.
• Competitive blocking with unlabeled TR23 substantially suppressed tumor uptake, confirming receptor-mediated specificity.
• SUVmax positively correlated with TROP-2 expression by immunohistochemistry across all three tumor types.

Automated summary

RadPigeon summaries are original and for information only. They are not clinical advice.