Quantitative CT AI identifies pulmonary fibrosis progression 16 months before clinical diagnosis

In a multicenter study, AI-powered quantitative CT detected radiological progression of pulmonary fibrosis an average of 16 months before clinical diagnosis, and a 1.5% increase in total disease extent on serial CTs was linked to higher mortality.

• The AI tool (Brainomix e-Lung, FDA-cleared) detected radiological progression up to 28 months earlier at one of three U.S. centers.
• A higher baseline weighted reticulovascular score was associated with increased risk of future pulmonary fibrosis.
• Findings come from a retrospective analysis of 509 patients; a prospective multicenter study (PROGRESS-PPF) is planned.

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