Automated 3D CT Body Composition Predicts Mortality After TAVR

Automated 3D CT body composition from noncontrast scans improved mortality prediction after transcatheter aortic valve replacement, beyond demographics/risk factors (Harrell C 0.66→0.71, P<0.001). Low subcutaneous fat volume & high fat attenuation = higher risk.

• Retrospective multicenter study of 915 TAVR patients; median follow-up 22 months, 17.5% mortality.
• Incorporating CT body composition measures improved discrimination for mortality beyond clinical factors (C-statistic 0.66 to 0.71, P<0.001).
• Lower subcutaneous fat volume and higher fat attenuation were associated with increased mortality, while greater skeletal muscle volume/attenuation conferred survival benefit.

Automated summary

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