Spectral CT Venous Iodine Concentration Tracks Perfusion Blood Volume in Gastric Cancer Invasion

Venous-phase spectral CT iodine concentration correlates strongly with perfusion CT blood volume (ρ=0.751, P<0.001) for detecting lymphovascular/perineural invasion in gastric cancer, per a prospective study of 87 patients.

• Venous-phase iodine concentration showed strong positive correlation with blood volume (Spearman ρ=0.751, P<0.001).
• A combined spectral+perfusion model achieved an AUC of 0.862 (F1 0.892) for invasion detection.

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