Multimodal MRI Reveals White Matter Changes and Impaired Neurovascular Coupling in Young Migraine Patients

Multimodal MRI in 130 patients with migraine without aura vs 110 controls showed increased white matter free water and mean diffusivity, reduced global neurovascular coupling, and altered regional coupling ratios. Random forest classification AUC=0.866. Chain mediation linked th…

• Patients had significantly increased global free water (FW) fraction and peak width of skeletonized mean diffusivity (PSMD), and reduced global neurovascular coupling (NVC).
• Random forest classifier achieved an area under the curve (AUC) of 0.866 for distinguishing patients from healthy controls.
• Limitation: Cross-sectional design and lack of independent validation; the authors note that longitudinal and prospective studies are required.

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