CT Radiomics Model Predicts Long-Term Renal Prognosis in AAV

A radiomics-clinical model using renal volume, creatinine, and C3 predicted 3-year end-stage renal disease with AUC 0.93 vs 0.91 for clinical-only in 262 ANCA-associated vasculitis patients.

• Retrospective cohort of 262 AAV patients (mean follow-up 40.8 months); 23% developed ESRD.
• Renal volume was independently associated with ESRD (Wald p=0.004).
• The combined model improved risk reclassification for the 3-year composite outcome (IDI p=0.018, NRI p=0.024).

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