Standard renal CT predicts glomerular filtration rate more accurately than creatinine or cystatin C formulas

CT-derived GFR showed the strongest correlation with measured iohexol clearance (R²=0.77) and lower mean absolute error (12.8 mL/min) vs. Cockcroft-Gault (15.6), cystatin C-based (14.2), and Lund-Malmö (13.0) estimates. Routine renal CT can precisely estimate kidney function.

• Multivariate regression combining CT segmentation-derived variable, body surface area, and age achieved adjusted R²=0.77 compared to iohexol-measured GFR (p<0.001).
• Mean absolute error for CT-estimated GFR (12.8 mL/min) was lower than all comparison formulas, and automatic segmentation performed similarly to manual.
• Patients evaluated for cisplatin therapy had greater variability in split renal function by CT than living kidney donors.

Automated summary

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