Unified framework enables controllable, domain-robust multimodal brain MRI synthesis

A unified framework synthesized multimodal brain MRI with controllability and domain robustness across 991 test subjects, matching baselines without finetuning on unseen domains; a clinician Turing test showed realistic appearance.

• Matched or outperformed advanced baselines for in-domain and unseen domain synthesis without finetuning.
• Balanced soft-plus-hard conditioning allowed smooth user adjustment of contrast weighting.
• Clinician Turing test and glioma grading indicated realistic appearance and preservation of pathology-relevant information.

Automated summary

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