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Thyroid AUS nodules: ACR TI-RADS TR5 carries 55% malignancy rate in prospective study
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgeryyesterday
In 71 thyroid nodules with atypia of undetermined significance, American College of Radiology TI-RADS was associated with malignancy (p=0.025): malignancy rates were 21% for TR3, 8% for TR4, and 55% for TR5.
- Prospective single-centre study of 71 AUS nodules from 67 patients; overall malignancy rate 20% (37% nuclear atypia, 63% other atypia).
- ACR TI-RADS score was significantly associated with malignancy (p=0.025); malignancy rates by category were TR3 21%, TR4 8%, and TR5 55%.
- Echogenic foci presence/type was associated with malignancy (p=0.001); peripheral calcifications were significantly associated. A relatively high follicular thyroid carcinoma case mix may have masked ultrasound predictive value, so larger cohorts would strengthen findings.
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