Silent VCFs found in 14.6% of DXA scans, more common in men

In 2446 asymptomatic UK Biobank participants, 14.6% had moderate/severe vertebral fractures on DXA. More common in men (18.8% vs 10.8% women); adjusted OR for women 0.51 (0.40–0.66). BMD and conventional risk factors poorly predicted fractures.

• Prevalence increased with age, from 9.4% at 40–49 years to 19.6% at 70–79 years.
• Fractures frequently occurred in individuals with normal bone mineral density, and conventional clinical risk factors had limited predictive value.

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