DENSE-2 Trial to Compare Contrast-enhanced Mammography and Abbreviated MRI for Supplemental Screening in Extremely Dense Breasts

The DENSE-2 randomized controlled trial, embedded in Dutch screening, will compare contrast-enhanced mammography and abbreviated MRI for supplemental screening in women with extremely dense breasts after negative mammography, aiming to reduce interval cancers. (ClinicalTrials.go…

• Multicenter RCT with two consecutive screening rounds, same technique each time (CEM or AB-MRI) after negative mammography.
• Primary aim: reduction of interval cancers versus mammography alone.
• Addresses cost and capacity barriers of full-protocol MRI in population screening.

Automated summary

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