Endovascular Stent-Graft for Islet Cell Delivery Shows Glucose-Responsive Insulin Secretion on Benchtop

Endovascular stent-graft housing islets showed glucose-responsive insulin secretion in benchtop model: murine islet insulin 83 vs 145 μIU/mL (low vs high glucose, p=0.02); human islet 229 vs 300 μIU/mL (p=0.014).

• Computational fluid dynamics modeling evaluated candidate device geometries under idealized, non-physiologic single-fluid conditions.
• In vivo evaluation of islet viability, immunoisolation, and hemodynamic impact is required before clinical translation.

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