Ex vivo validation of OFDI for detecting intimal versus medial calcification in a single femoropopliteal lesion

Optical frequency domain imaging (OFDI) detected 60.2% of histologically confirmed calcifications in a single ex vivo femoropopliteal lesion, with much lower sensitivity for medial (30.8%) than intimal (72.3%) calcification.

• Internal elastic lamina was not identified in 52.6% of OFDI images, consistent with limited medial layer visualization.
• Ex vivo co-registration study of 38 cross-sections from a single patient, providing histologic ground truth.

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