MRI links weaker cerebellar-amygdala-thalamic circuit connectivity to adolescent anxiety

MRI analysis of nearly 3,500 adolescents reveals that weaker connections in a cerebellum-amygdala-thalamus circuit are associated with greater anxiety, while more efficient temporoparietal and frontoparietal networks may be protective. The brain differences were detectable as ea…

• Structural brain differences were also linked to anxiety and lower visuospatial skills.
• The imaging findings were measurable in children as young as 11, marking early adolescence as a critical period.
• The authors see potential for precision psychiatry interventions targeting these circuits pending further validation.

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