Automated whole-liver quantification on gadoxetic acid MRI matches manual indices

Automated phase-adaptive whole-liver segmentation achieved Dice 0.998-0.999 and reader-model agreement for liver indices of 0.936-0.977 on gadoxetic acid MRI; hepatobiliary uptake indices (HUI, LSR, RLE, LMR) were lower in cirrhosis (p<0.001).

• Retrospective single-center study included 1,174 patients; the phase-adaptive nnU-Net was trained on 403 and tested on 500 dynamic MRI sequences, with manual validation in 50 patients.
• Hepatocellular uptake index, liver-to-spleen ratio, relative liver enhancement, and liver-to-muscle ratio were lower in cirrhosis (p<0.001); arterial enhancement fraction did not differ (p=0.14).

Automated summary

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