Quantitative MRI Measurements of Olfactory Sulcus and Bulb Show Reproducibility in Septo-Optic Dysplasia Spectrum

BPD-normalized olfactory sulcus depth, length, and olfactory bulb width showed moderate reproducibility (ICC 0.58–0.69) in 37 patients with septo-optic dysplasia spectrum and were significantly associated with consensus abnormality scores (P < .001–.01).

• Ordinal olfactory system abnormality scoring showed low inter-reader agreement, while continuous normalized metrics had ICCs 0.58–0.69.
• Associations with consensus scores remained significant in the subgroup with classic septo-optic dysplasia or SOD-plus (n=25).
• Single-center retrospective design limits generalizability.

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