SWI intratumoral susceptibility signals: meta-analysis of threshold grading for glioma

For distinguishing WHO grade III-IV from grade II gliomas, an ITSS threshold ≥2 yielded pooled sensitivity 0.85 (95% CI 0.74-0.91) and specificity 0.93 (0.84-0.97), the most balanced profile.

• Pooled sensitivity/specificity were 0.96/0.48 at threshold ≥1, 0.85/0.93 at ≥2, and 0.72/0.97 at ≥3.
• Higher ITSS burden was most consistently associated with IDH wild-type status across heterogeneous molecular studies.
• Limitation: predominantly retrospective, single-center studies with heterogeneous ITSS scoring, imaging protocols, and WHO reference standards.

Automated summary

RadPigeon summaries are original and for information only. They are not clinical advice.