CT radiomics plus clinical predictors improve early PTH prediction in TBI

A CT radiomics–clinical fusion model predicted post-traumatic hydrocephalus after traumatic brain injury with an AUC of 0.865 in temporal validation, outperforming clinical-only (AUC 0.769) and radiomics-only (AUC 0.783).

• Features were extracted from 14 automatically segmented intracranial regions on the last preoperative CT, using mutual information filtering and LASSO regression for feature selection.
• The fusion model not only had higher discrimination but also demonstrated acceptable calibration and greater net benefit on decision curve analysis in the temporal validation cohort.

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