CT characteristics linked to lung cancer histologic subtypes in screening trial

In 213 NELTON trial lung cancers, pleural attachment on CT associated with adenocarcinoma (odds ratio 6.67, 95% CI 1.20–33.33); larger size (OR 0.92 per mm) and lower/middle lobe location reduced odds. Pattern may aid subtype prediction.

• Adenocarcinomas were smaller (mean 14.6 vs 17.3 mm), slower-growing (volume doubling time OR 5.65), and more often pleural-based or located in the right upper lobe (49.3% vs 31.9%).
• Multivariable model had AUC 0.75, sensitivity 96%, specificity 29%.

Automated summary

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