Radiomic Texture Features Stable Across CT to Micro-CT in NSCLC, Distinguishing Histotypes

Four texture radiomic features were reproducible across in vivo CT, ex vivo CT, and micro-CT in NSCLC after normalization and volume matching, and reliably distinguished adenocarcinoma from squamous cell carcinoma.

• After intensity normalization and volume-matched subsampling, four texture features—DependenceNonUniformity, GrayLevelNonUniformity (GLDM and GLRLM), and Coarseness (NGTDM)—showed high cross-modality reproducibility.
• These features differentiated adenocarcinoma from squamous cell carcinoma, suggesting potential as transferable biomarkers for tumor biology.

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