ECT reduces Hurst index in middle cingulate cortex, decouples it from posterior cingulate

In 46 patients with major depression, ECT significantly reduced the Hurst index (excitation-inhibition balance) in the middle cingulate cortex and decoupled it from posterior cingulate, with changes linked to dopamine and histamine maps and synaptic genes.

• Changes in Hurst index were associated with cortical myelination and glucose metabolism patterns.
• Spatial transcriptomic analysis revealed enrichment in excitatory neurons, astrocytes, and oligodendrocytes, particularly in glutamatergic synapse pathways.

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