Dynamic vasoactive response maps reveal distinct white matter hemodynamics

Excluding reverse-steal exams reveals significantly lower white matter maximum cerebrovascular reactivity ipsilateral to stenosis (β=-0.579; 95% CI -0.794 to -0.36; P<0.001); reverse-steal exams had delayed time-to-maximum (P=0.004).

• Full cohort: ipsilateral white matter hyperintensities had the lowest CVRmax but did not reach statistical significance (β=-0.211, P=0.08).
• After excluding 8 exams with reverse-steal profiles, ipsilateral CVRmax was significantly reduced (β=-0.579, P<0.001).
• Reverse-steal examinations demonstrated delayed ipsilateral time-to-maximum (CVRTmax) (P=0.004) and higher terminal-to-maximum CVR ratios (P=0.03).

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