VQGAN Synthesizes Amyloid PET from Structural MRI for Alzheimer's Staging

Synthetic amyloid PET from structural MRI accurately captured Alzheimer's disease-stage differences (p<0.05) across 431 subjects, outperforming other models in image quality.

• In 431 ADNI subjects, synthetic Aβ-PET distinguished cognitively normal, MCI, and AD dementia with significant regional uptake differences (p<0.05).
• The VQGAN model achieved lower mean absolute error and higher structural similarity than other generative models.

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