QIBA Guidelines Set 19% Stiffness Change Threshold for Reliable Liver MR Elastography

New QIBA guidelines for liver MR elastography state that a ≥19% change in stiffness represents a true biologic change (95% confidence), based on a within-subject coefficient of variation of ~7%. The guidelines standardize acquisition, reconstruction, and analysis for reproducibl…

• Issued by the Quantitative Imaging Biomarkers Alliance (now the Quantitative Medical Imaging Coalition) for chronic liver disease.
• Defines standardized acquisition protocols, reconstruction requirements, image quality assurance, and analysis methods to minimize variability across scanners and institutions.
• A measured liver stiffness change of at least 19% (derived from a within-subject coefficient of variation of ~7%) indicates a true biologic change with 95% confidence.

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