Preclinical Models in Interventional Oncology: Animal Platforms and New Human-Based Alternatives

Interventional oncology research leverages animal models (mouse, rat, woodchuck, rabbit, pig, dog, non-human primate) alongside new approach methodologies like organoids, organ-on-a-chip, and AI in silico models to complement human biology-based testing.

• Next-generation animal models include humanized, genetically defined, and comorbidity models.
• New approach methodologies (NAMs) encompass organoids, organ-on-a-chip, ex vivo organ preparations, and artificial intelligence/in silico tools.
• Model selection in the NAM era considers the complementary value of traditional and alternative approaches.

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