Tentorial adjacency may heighten entorhinal tau risk in Alzheimer's progression

Tau PET signal in the entorhinal cortex predicted progression from mild cognitive impairment to Alzheimer's disease only in patients whose entorhinal cortex was close to the tentorial incisura, suggesting chronic mechanical stress may play a role (p=0.036, n=47).

• A neuroanatomical contact coefficient quantified EC-tentorial incisura proximity from multimodal imaging.
• In the high adjacency group, tau PET predicted conversion (p=0.036); no prediction in the low adjacency group.

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