Nuclear / MolecularBody / AbdominalResearchTrainee

First-in-human PET/CT dosimetry of 89Zr-labeled leukocytes shows low radiation dose

European journal of nuclear medicine and molecular imagingyesterday

First-in-human PET/CT with [89Zr]Zr-oxine-labeled leukocytes showed favorable dosimetry: mean effective dose 0.92 mSv/MBq, lower than predicted 1.14 from indium-111 (P=0.006). Safe in 4 healthy women.

  • The highest mean absorbed-dose coefficients were in spleen (3.52 mGy/MBq), liver (2.1), and adrenals (1.62).
  • PET enabled visualization of leukocyte distribution and temporal dynamics.
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