FFR-CT Adds Modest Prognostic Gain Beyond Stenosis in Large CCTA Cohort

In 7,836 coronary computed tomography angiography (CCTA) patients, fractional flow reserve from CT (FFR-CT) ≤0.70 carried roughly threefold higher myocardial infarction risk; adding FFR-CT to risk factors and stenosis severity improved C-index only 0.771 to 0.783.

• After adjustment for risk factors and CAD-RADS, stenosis-specific FFR-CT ≤0.70 was associated with approximately threefold higher myocardial infarction risk.
• The optimal FFR-CT threshold for myocardial infarction or cardiovascular death was 0.67, substantially lower than the conventional 0.80 ischemic threshold.
• The author argues future comparisons should include quantitative plaque burden and plaque phenotype, not just stenosis plus FFR-CT.

Automated summary

RadPigeon summaries are original and for information only. They are not clinical advice.