Neonatal MRI count of enlarged perivascular spaces correlates with perinatal asphyxia severity and later sleep quality

In 319 neonates with perinatal asphyxia, MRI count of enlarged perivascular spaces was independently associated with brain injury severity (p=0.0001) and, in severe cases, later sleep disturbance (r=0.3365, p=0.0061).

• 319 neonates with perinatal asphyxia were categorized as mild (n=229) or severe (n=90); clinical, amplitude-integrated EEG, and cranial MRI data were collected.
• Multivariable regression showed EPVS count independently related to severity in all infants (p=0.0001), mild group (p=0.0248), and severe group (p=0.0114).
• In the severe PA group, higher EPVS count correlated with worse long-term sleep quality (r=0.3365, p=0.0061).

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