Left DTI-ALPS index lower in heart failure with preserved EF, associated with cognitive impairment

Heart failure with preserved ejection fraction (HFpEF) patients showed lower left brain perivascular diffusion (DTI-ALPS 1.64 vs 1.77, p=0.04) and worse cognition. Adjusted β for MoCA: 0.021 (p=0.007). Cross-sectional.

• Cross-sectional design; causal and predictive interpretations should be avoided until longitudinal studies confirm.
• Right and mean DTI-ALPS indices did not differ significantly between patients and controls.
• Lower left DTI-ALPS index was independently associated with worse delayed recall (β=0.050, p=0.009).

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