Neighborhood Disadvantage Linked to Lower Brain Volumes in Men on Clinical MRI

In a clinical brain MRI study of 2,863 patients, greater neighborhood socioeconomic disadvantage was linked to lower brain volumes in cerebellar, frontal, and medial temporal networks in men but not women. Only cerebellar network association remained significant in sex-interacti…

• Male patients: cerebellar β=-0.006 (95% CI -0.009 to -0.003, P<.001), medial temporal β=-0.004 (95% CI -0.007 to -0.001, P=.01), frontal β=-0.004 (95% CI -0.007 to -0.0004, P=.04).
• No significant associations in female patients; sex interaction significant only for cerebellar network (β=-0.005, P=.01).

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