Nuclear / MolecularCardiacResearch

Virtual planar SPECT images yield accurate H/CL ratios in cardiac amyloidosis

Annals of nuclear medicineyesterday

Virtual planar images derived from SPECT provide comparable heart-to-contralateral lung ratios to standard planar imaging for 99mTc-PYP cardiac amyloidosis, with correlation ≥0.97 and statistical equivalence under attenuation and scatter corrections.

  • Retrospective study of 41 patients with suspected transthyretin cardiac amyloidosis.
  • H/CL ratios from AutoPlanar and planar images highly correlated (r ≥ 0.97), with Bland-Altman biases from -0.087 to -0.027.
  • Equivalence demonstrated with attenuation and scatter corrections (ACRR, ACSCRR) but not with resolution recovery alone.
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