Prostate MRI ellipsoid formula shows high accuracy for volume and PSA density, with caveat for large glands

Ellipsoid formula for MRI prostate volume shows excellent agreement with manual segmentation (ICC 0.985, mean absolute difference 5.5 cc) and yields sensitivities 0.86–0.95 and specificities 0.88–0.97 for PSA density cut-offs in 328 men. Underestimation occurs in glands >80 cc b…

• Optimal volume-dependent weighting factors ranged from 0.50 to 0.54, but statistical modeling showed no significant improvement over the fixed 0.52 factor.
• For PSA density thresholds of 0.1, 0.15, and 0.2 ng/mL/cc, ellipsoid-based sensitivity was 0.86–0.95 and specificity 0.88–0.97 compared with manual segmentation.

Automated summary

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