Brain MRI Surveillance Alone Preserves Cognition Better Than MRI Plus PCI in SCLC

Brain MRI surveillance alone improved cognitive failure-free survival by 40% vs. MRI plus prophylactic cranial irradiation in small cell lung cancer (SCLC), with no overall survival difference, supporting it as standard care.

• Brain MRI surveillance alone yielded a 40% improvement in cognitive failure-free survival vs. MRI plus prophylactic cranial irradiation.
• Preliminary overall survival data (based on 128 deaths) showed no significant difference between the two strategies.
• MRI alone was associated with longitudinal improvements in patient-reported outcomes and quality of life.

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