Reduced Interhemispheric Precentral Gyri Connectivity Marks Acute Basal Ganglia Ischemic Stroke

Reduced interhemispheric functional connectivity between bilateral precentral gyri distinguished acute basal ganglia ischemic stroke from controls (AUC 0.877 SVM, 0.868 LR), linked to synaptic and metabolic gene signatures.

• Local connectivity: Decreased regional homogeneity (ReHo) in bilateral precentral gyri.
• Classification: SVM and LR models distinguished patients from controls with AUCs of 0.877 and 0.868; reduced interhemispheric FC was the top SHAP feature.
• Transcriptomic: Genes correlated with this FC disruption were enriched for synaptic function, ion homeostasis, and energy metabolism.

Automated summary

RadPigeon summaries are original and for information only. They are not clinical advice.