Tau PET imaging best predicts cognitive decline among AT(N) biomarkers in ADNI cohort

In 383 Alzheimer’s Disease Neuroimaging Initiative participants, tau PET biomarkers most accurately predicted cognitive decline, matching models combining all three imaging pathology measures. Binarized biomarkers largely preserved accuracy, and imaging consistently outperformed…

• Binarization of biomarkers mostly preserved accuracy, while support vector machines trained on brain-wide pathology generally did not improve performance.
• Imaging-based biomarkers consistently outperformed cerebrospinal fluid and plasma biofluid markers in a subsample.

Automated summary

RadPigeon summaries are original and for information only. They are not clinical advice.