White matter hyperintensities disrupt structural connectivity more in cerebral small vessel disease than dementia

White matter hyperintensities (WMH) disrupt brain structural networks differently in cerebral small vessel disease vs dementia, with stronger correlation to connectivity changes in at-risk individuals (r=-0.32) than dementia (r=-0.03).

• Widespread disruption of structural brain networks was observed in both individuals at risk for cerebral small vessel disease and dementia compared with healthy controls.
• Disruptions were partially explained by individual differences in WMH volume and location.

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