Prospective study protocol investigates gut-brain axis and long-term TBI recovery with advanced imaging and biomarkers

The OVERCOME-TBI study protocol will use MRI, PET, and biosampling to identify biomarkers of neurodegeneration and gut-brain disruption in up to 160 TBI patients followed for 2–15 years post-injury.

• Prospective observational design combining two cohorts with acute data and new chronic-phase assessments at 2–5 and 12–15 years post-TBI.
• Multimodal imaging includes advanced MRI (multishell diffusion, resting-state fMRI) and [11C]PK11195 PET to assess neuroinflammation.
• Primary outcomes are neuroinflammatory burden (PET and blood biomarkers), functional outcomes (Glasgow Outcome Scale Extended), and gut microbiota composition.

Automated summary

RadPigeon summaries are original and for information only. They are not clinical advice.