FAPI PET's potential in non-oncologic fibrosis imaging

Fibroblast activation protein (FAP)-directed PET shows promise as an imaging biomarker for active tissue remodeling in nonmalignant diseases like cardiac fibrosis, vasculitis, and interstitial lung disease, but current clinical evidence remains largely exploratory.

• FAP expression is not cancer-specific but is tightly coupled to tissue remodeling, inflammation, and fibrosis in many nonmalignant diseases.
• Early data in cardiac, vascular, and rheumatologic conditions suggest FAP-directed PET may help monitor disease activity.
• Supporting evidence comes primarily from early-stage studies; further investigation is needed before clinical adoption.

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