CardiacAI / InformaticsResearch

Angiography-derived radial wall strain predicts long-term events in untreated coronary vessels after PCI

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiologyyesterday

After percutaneous coronary intervention, elevated radial wall strain (RWSmax ≥13%) predicted 5-year non-target vessel events: adjusted hazard ratio 4.82 (95% CI 3.14-7.40, p<0.0001); AUC 0.73, with non-target revascularization AUC 0.92.

  • Retrospective post hoc analysis of the TARGET All Comers randomized trial included 1,551 patients; AI-based radial wall strain was computable in 1,384 non-target vessels from 802 patients.
  • A prespecified RWSmax cutoff of 13% or greater independently predicted the non-target vessel-oriented composite endpoint, with adjusted HR 4.82 (95% CI 3.14-7.40, p<0.0001) and adjusted AUC 0.73 (95% CI 0.69-0.78, p<0.0001).
  • Prediction was strongest for non-target vessel revascularization (adjusted AUC 0.92, 95% CI 0.88-0.95; p<0.0001) and improved in high-quality angiographic images (adjusted HR 6.89, 95% CI 3.15-15.07; p<0.0001).
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