PSA density and age-based model predicts significant prostate cancer in PI-RADS 3 MRI lesions

A model using PSA density and age predicted clinically significant prostate cancer in men with PI-RADS 3 MRI lesions (AUC 0.846 in external validation of 122 men).

• Clinically significant prostate cancer (ISUP Grade Group ≥2) was found in 24.2% of the development cohort and 25.4% of the external validation cohort.
• The retrospective model showed good calibration and decision curve analysis, but further validation in larger, more diverse cohorts is required before clinical use.

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