Brain Structural-Functional Coupling Mediates Paternal Education Link to BMI and Depression

In 490 young adults, paternal education was associated with BMI and depressive scores, statistically mediated by structural-functional connectivity coupling in the right inferior parietal lobule (indirect effect 0.01, 95% CI 0.001–0.04). No maternal link found. Cross-sectional M…

• Paternal education correlated positively with BMI (r=0.10) and negatively with depressive scores (r=-0.09); no significant associations for maternal education.
• SC-FC coupling in the right inferior parietal lobule showed positive correlations with paternal education (r=0.19), BMI (r=0.12), and depressive scores (r=0.10).
• Mediation analysis: Right IPL SC-FC coupling statistically mediated the paternal education–BMI association (indirect effect 0.01, 95% CI 0.001–0.04) and paternal education–depression association (indirect effect 0.01, 95% CI 0.001–0.03).

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