Multimodal CT Enterography Radiomics and CRP Model for Mucosal Healing in Small Bowel Crohn's Disease with Prospective Validation

Multimodal model combining CT enterography radiomics and C-reactive protein (CRP) achieved AUCs 0.860 (internal) and 0.842 (external) for mucosal healing in small bowel Crohn’s disease, outperforming CRP alone (p<0.05) with prospective validation.

• Multicenter study with retrospective training (n=114), internal validation (n=50), external test (n=42), and prospective validation (n=20); mucosal healing rates varied across cohorts (52.6%, 54.0%, 21.4%).
• The LASSO-XGBoost radiomics model achieved AUC 0.824 in the prospective cohort; the final multimodal model (CRP + radiomics) significantly outperformed the CRP-alone clinical model (p<0.05).
• SHAP analysis identified CRP and two radiomics features as top predictors, providing interpretable outputs.

Automated summary

RadPigeon summaries are original and for information only. They are not clinical advice.