Radiomics model combining ADC and ASL MRI predicts ATRX status in glioblastoma

Radiomics model combining ADC and ASL MRI predicted ATRX status in glioblastoma: AUC 0.711, sensitivity 0.737, specificity 0.690 in 106 patients. SHAP showed balanced modality contribution. Low PPV limits to screening.

• SHAP analysis revealed ADC- and ASL-derived features accounted for 48.5% and 51.5% of total mean absolute SHAP importance, respectively.
• Decision curve analysis showed net benefit at threshold probabilities of approximately 0.01 to 0.46.
• Model is best regarded as a hypothesis-generating screening adjunct due to moderate calibration and modest positive predictive value.

Automated summary

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