Low-field uterine diffusion MRI distinguishes adenomyosis from healthy tissue

At 0.55T, uterine diffusion MRI (ADC/IVIM) differentiated adenomyosis from healthy tissue: reduced myometrial ADC (p=0.024), lower endometrial diffusivity (p=0.017), increased perfusion fraction (p=0.014) in 106 women. Menstrual phase and hormonal status also influence metrics.

• Prospective study of 106 women: 47 healthy without hormonal contraception, 37 with hormonal contraception, and 22 with adenomyosis.
• Uterine diffusion metrics varied with menstrual phase (increased endometrial diffusivity in luteal phase, p=0.024) and with hormonal therapy.
• Repeat measurements and inter-annotator agreement demonstrated good consistency, supporting feasibility of 0.55-T IVIM.

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