Inflammatory and lipid indices associated with pulmonary nodules on screening CT

In 1,072 adults having health-exam chest CT, higher atherogenic index of plasma (OR 1.38, 95% CI 1.16-1.64) and systemic inflammation response index (OR 1.37, 1.14-1.64) were independently associated with pulmonary nodules; adding indices did not significantly improve AUC (0.77…

• Cross-sectional study of 1,072 adults undergoing routine health-exam CT; 35.54% had a pulmonary nodule and 10.17% had Lung-RADS category ≥3.
• In mutually adjusted representative-index model, AIP (OR 1.38, 95% CI 1.16–1.64) and SIRI (OR 1.37, 95% CI 1.14–1.64) were associated with any pulmonary nodule; no significant AUC gain from derived-index model (0.77 vs 0.76, P=0.100).
• SIRI was associated with Lung-RADS ≥3 (OR 1.48, 95% CI 1.15–1.91), but low events per variable (6.41) warrants cautious interpretation; cross-sectional design cannot establish causality.

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