Multicenter MRI radiomics predicts survival in pediatric non-midline high-grade glioma

In 77 children with non-midline high-grade glioma, MRI radiomics plus age and sex predicted overall survival with a concordance of 0.78 (95% CI 0.70-0.83); high-risk patients had median survival 21.7 vs 44.6 months.

• Radiomics features alone yielded concordance 0.75 (95% CI 0.69-0.82), versus 0.61 (95% CI 0.54-0.67) for age and sex alone.
• High-risk versus low-risk radiomics groups had a hazard ratio of 2.42 (95% CI 1.26-4.66) for overall survival.
• This multicenter pilot study used 1800 IBSI-based radiomics features from pre-treatment gadolinium-enhanced T1- and T2-weighted MRI.

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