Choroid plexus volume on MRI tracks tumor location and histology rather than grade

In 811 brain tumor patients vs 744 controls, choroid plexus volume was larger for infratentorial than supratentorial tumors (P<0.001), not independently tied to grade. Pediatric high-grade gliomas and glioneuronal/neuronal tumors exceeded adult diffuse gliomas (P<0.01).

• Among 811 patients with histologically confirmed gliomas or glioneuronal/neuronal tumors and 744 controls, choroid plexus volume was automatically segmented on preoperative 3D T1-weighted MRI with deep learning and expert quality control.
• Tumor grade showed no independent association with choroid plexus volume after adjustment; pediatric-type diffuse high-grade gliomas and GNTs had larger volumes than adult-type diffuse gliomas (P < 0.01).
• Exploratory molecular analysis linked +7/−10 status in adult-type diffuse gliomas to lower choroid plexus volume (β = −0.127, P = 0.009), though this requires validation in this retrospective observational cohort.

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